Abstract
Continuous glucose monitoring devices measure glucose in interstitial fluid. The devices are effective when used by patients with type 1 and 2 diabetes but are increasingly being used by researchers who are interested in the effects of various behaviours of glucose concentrations in healthy participants. Despite their more frequent application in this setting, the devices have not yet been validated for use under such conditions. A total of 124 healthy participants were recruited to a ten-day laboratory study. Each participant underwent four oral glucose tolerance tests, and a total of 3315 out of a possible 4960 paired samples were included in the final analysis. Bland–Altman plots and mean absolute relative differences were used to determine the agreement between the two methods. Bland–Altman analyses revealed that the continuous glucose monitoring devices had proportional bias (R = 0.028, p < 0.001) and a mean bias of −0.048 mmol/L, and device measurements were more variable as glucose concentrations increased. Ninety-nine per cent of paired values were in Zones A and B of the Parkes Error Grid plot, and there was an overall mean absolute relative difference of 16.2% (±15.8%). There was variability in the continuous glucose monitoring devices, and this variability was higher when glucose concentrations were higher. If researchers were to use continuous glucose monitoring devices to measure glucose concentrations during an oral glucose tolerance test in healthy participants, this variability would need to be considered.
Highlights
The accurate measurement of glucose concentrations is critical in research where the impact of behaviours or psychological states on glucose concentrations is of interest
Measuring glucose concentrations has been conducted by drawing blood from participants [1], but it can be achieved with the use of continuous glucose monitoring devices
A total of 3315 glucose values from blood plasma were paired with glucose values from continuous glucose monitoring devices
Summary
The accurate measurement of glucose concentrations is critical in research where the impact of behaviours or psychological states on glucose concentrations is of interest. Measuring glucose concentrations has been conducted by drawing blood from participants [1], but it can be achieved with the use of continuous glucose monitoring devices. Continuous glucose monitoring devices measure glucose concentrations in interstitial fluid. Due to the differing glucose dynamics in interstitial fluid and blood plasma, there is a need for these devices to be validated. The devices have been validated previously for their use in clinical settings, e.g., [2,3], but they have not been validated for use during an oral glucose tolerance test in healthy individuals—a research area where they have the potential to be a valuable tool [4]
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More From: International Journal of Environmental Research and Public Health
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