Abstract
Herein, the synthesis and characterization of two glucose-based degradable poly(ester amines), GluN3 and GluN4, are described. Data from gel shift assays, PicoGreen dye exclusion, and dynamic light scattering studies reveals that these polycations can form polyplexes with plasmid DNA at a relatively low N/P ratio and that the polymers degrade rapidly at physiological pH conditions. Assessment of in vitro data via flow cytometry and live cell fluorescence microscopy indicated that GluN3 and GluN4 polyplexes can be internalized by HeLa cells in a highly effective manner with low cytotoxicity profiles.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
