Abstract

Human serum albumin (HSA), due to its long life period, high concentration in plasma and its important roles in body homeostasis is attracted researcher activities for many years. Here HSA-glucose interaction in the range of normal and diabetic concentrations of glucose at 37oC and 42oC is investigated via pH metric, UV absorption spectroscopic and fluorescence methods. The findings indicted that high glucose concentration induces conformations change in HSA as like increment of temperature up to 42°C. It can be concluded that glucose in diabetic condition destabilizes HSA as well as fever.

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