Glucose and insulin metabolism in ruminating and veal calves fed high and low fat diets

Abstract

Holstein male calves were maintained on conventional (milk to 6 wk of age, fed grain and hay after weaning) and veal (milk replacer only) diets to 16 wk of age. Within each of these 2 physiological states (ruminating or non-ruminating), calves were fed low or high fat diets (ruminating: 3 and 10%; veal: 10 and 18%). Glucose tolerance tests were undertaken at 8 and 16 wk of age in each group. Basal concentrations (4 hr postfeeding) and areas under the response curves for plasma glucose and insulin were higher in veal calves ( P < .0001). Ruminating calves fed higher fat utilized glucose more readily (smaller areas under the curves for both glucose and insulin, P < .10) than those fed lower fat. Age did not influence basal glucose concentrations ( P > .10), but older calves had higher basal insulin ( P < .0001) and greater areas under the curves ( P < .0005) for both glucose and insulin after a glucose challenge. Rate of clearance (k) was greater in ruminating calves ( P < .001). Though rate of clearance in veal calves was slower, larger plasma pool size causd veal calves on average to utilize glucose at a 15% greater rate per kg body weight than ruminating calves. Whereas fat concentration in the diets did not influence glucose metabolism in veal calves, the high lactose content (> 50% of diet dry matter) of veal diets induced severe insulin resistance in these calves.