Glucose and Glucoregulatory Modulation of Memory Scanning, Event-Related Potentials and EEG in Elderly Subjects

Abstract

Endogenous P300b event-related potential (ERP) and behavioral performance measures, extracted during a visual memory scanning task, and spectral indices of resting electroencephalographic (EEG) activity, were assessed in 12 healthy elderly adults before and after double-blind oral administration of a placebo or glucose (50 mg) beverage. Glucoregulation was estimated by deriving a recovery index to categorize subjects as having better (BR) or poorer (PR) blood glucose recovery. Although glucoregulatory status did not impact on EEG or task performance, PR subjects exhibited reduced P300b areas relative to BR subjects prior to beverage administration. Glucose did not alter P300b or memory scanning performance but, regardless of glucoregulatory status, it increased the EEG power in the slow alpha frequency band. The study results suggest that peripheral glucoregulation can influence neuroelectric measures of cognition and that the acute ingestion of glucose can modulate central arousal processes.