Abstract
A hitherto undescribed variant of erythrocyte glucose-6-phosphate dehydrogenase (G-6-PD) activity, G-6-PD Boston, is described in a 24-year-old Caucasian male of Polish-Jewish ancestry. A marked decrease in red cell G-6-PD activity was associated, in this individual, with a compensated hemolytic process. The electrophoretic mobility of the partially purified enzyme on cellulose acetate at pH 9.1 and on starch gel was indistinguishable from normal but the apparent Km for both G-6-PD (18–21 μM) and NADP (1.7–2.2) was significantly decreased. Preliminary evidence supports the concept that G-6-PD Boston may not be extremely rare among this particular population group.
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