Abstract
Nowadays, magnetic hyperthermia is being extensively used in the treatment of cancer therapy due to its ability to kill cancer cells through the thermal effect. This study reports the synthesis of multifunctional Doxorubicin (DOX) loaded Gadolinium/Cobalt@Iron oxide-Dendrimer-Glucosamine-Nanoseed (Gd/Co@IO-D-G-NS) for the treatment of prostate cancer. Furthermore, glucosamine ligand was attached to enhance the effectiveness of nanoseeds via targeting glucose transporters. The release profile of DOX from Gd/Co@IO-D-G-NS nanoseeds was observed to be pH-dependent. The developed nanosseds showed acceptable hemocompatibility, and were able to produce combined hyperthermia and chemotherapeutic effect in vitro in PC3 cells. Moreover, cellular uptake studies revealed that nanoseeds were effectively uptaken by cancer cells through receptor-mediated endocytosis. It is expected that the outcome of this study will assist in progressing the know-how towards the development of nanoseeds for chemo-photothermal therapy of resectable cancers, including prostate and breast, to naming a few.
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