Abstract
AbstractBACKGROUNDThe bacterial strain Gluconobacter oxydans (ATCC 621H) was investigated for its potential biodetoxification properties through conversion of furfural to 2‐furoic acid (FA). Furfural is a common byproduct of lignocellulose feedstock pretreament processing and it is a putative inhibitor of several important microbial pathways.RESULTSBoth furfural and furfuryl alcohol exhibit significant substrate inhibition to biooxidation. To overcome this inhibition, a fed‐batch bioprocess was developed to convert furfural and furfuryl alcohol to the low‐toxic FA product. The optimized fed‐batch bioprocess gave FA concentrations exceeding 40 g L−1 with a productivity of 0.167 g L−1 h−1 and a yield of nearly 100%. In order to improve productivity, the whole cell catalysis was carried out in a compressed oxygen supply‐sealed and stirred tank reactor (COS‐SSTR). Similar to the flask studies, 38.18 g L−1 FA was obtained in 24 h.CONCLUSIONGluconobacter oxydans was found to oxidize both furfural and furfuryl alcohol to a single product, FA, with a yield close to 100%. Unlike other microorganisms, this strain does not have a metabolic system to further degrade FA, demonstrating its potential to produce this useful product from renewable resources. © 2016 Society of Chemical Industry
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