“Glucono-delta-lactone” as a substrate for preparation of new magnetically recoverable nanocatalyst for the environmentally benign synthesis of novel azo linked 3-methyl-isoxazol-5-ones

Abstract

Silica-coated Fe3O4 nanoparticles bound to Glucono-delta-lactone (GDL) magnetic nanoparticles (Fe3O4@SiPr@GDL MNPs) were prepared and characterized by TEM, EDX, TGA/DTG, Zeta Potential, BET, FE-SEM, XRD, FTIR and VSM. Fe3O4@SiPr@GDL MNPs have been shown to be effective catalysts for the synthesis of the isoxazol-5(4H)-one system. The advantages of this method are efficiency, clean protocol, easy handling, high yield, shorter reaction time and availability of catalyst. The catalyst can be rapidly recovered and reused for six cycles with almost constant activity. The newly synthesized compounds were characterized by 1H NMR, 13C NMR and FTIR spectra and elemental analysis.