Abstract
Jejunal mucosa of the guinea pig contains significant activities for the important, rate-limiting enzymes of gluconeogeneses: glucose-6-phosphatase (EC 3.1.3.9), fructosediphosphatase (EC 3.1.3.11), phosphopyruvate carboxykinase (EC 4.1.1.32), and pyruvate carboxylase (EC 6.4.1.1). Homogenates of jejunal mucosa from 72-h starved guinea pigs had glucose production rates of 4.8 ± 0.3 μmoles/h per g mucosa. These studies suggest that intestinal mucosa may be an important source of glucose production in the starved guinea pig.
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