Abstract
Glucocorticosteroids for people with alcoholic hepatitis.
Highlights
Alcoholic hepatitis is a form of alcoholic liver disease characterised by steatosis, necroinflammation, fibrosis, and complications to the liver
We presented the results of dichotomous outcomes as risk ratios (RR) and of continuous outcomes as mean di erence (MD), with 95% confidence intervals (CI)
We presented the results of dichotomous outcomes of individual trials as RR with 95% CI and the results of the continuous outcomes as MD with 95% CI and Trial Sequential Analysis-adjusted CI
Summary
Alcoholic hepatitis is a form of alcoholic liver disease characterised by steatosis, necroinflammation, fibrosis, and complications to the liver. The term 'alcoholic hepatitis' was used for the first time in a paper by Beckett and colleagues in 1961 (Beckett 1961), but clinical jaundice a er excessive ethanol consumption was reported in the literature long before that, in 1912 (French 1912; Gerber 1973). Most probably, these reports represented people with alcoholic hepatitis (Mendenhall 1984; Jensen 1994). In 20% to 40% of persistent heavy drinkers (defined as alcohol consumption per day of more than 30 g in men (EASL 2018) and more than 20 g in women (EASL 2018), alcoholic hepatitis and other complications may develop (WHO 2013)
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