Abstract
Our original manuscript, indicating normal T-cell development and selection in the thymus of glucocorticoid receptor (GR)−/− mice 1 Purton J.F. et al. Intrathymic T-cell development and selection proceeds normally in the absence of glucocorticoid receptor signaling. Immunity. 2000; 13: 179-186 Abstract Full Text Full Text PDF PubMed Scopus (101) Google Scholar , and our follow-up viewpoint 2 Godfrey D.I. et al. Stress free T-cell development: glucocorticoids are not obligatory. Immunol. Today. 2000; 21: 606-611 Abstract Full Text Full Text PDF PubMed Scopus (46) Google Scholar , discussing the controversy surrounding this field, have certainly promoted much discussion. Recently, we responded to a letter from Ashwell and colleagues 3 Ashwell J.D. et al. Do glucocorticoids participate in intrathymic T-cell development?. Immunol. Today. 2000; 21: 644-645 Abstract Full Text Full Text PDF PubMed Scopus (33) Google Scholar , and discussed the possible reasons why GR antisense transgenic mice have a significant reduction in thymocyte numbers, as opposed to GR−/− mice, which have normal thymocyte numbers and apparently normal thymocyte selection 4 Godfrey D.I. Reply to Ashwell, Vacchio and Galon. Immunol. Today. 2000; 21: 645-646 Abstract Full Text Full Text PDF Google Scholar . In the April issue of this journal, a letter from Jondal and Okret 5 Jondal M. Okret S. A role for glucocorticoids in the thymus?. Trends Immunol. 2001; 22: 185-186 Abstract Full Text Full Text PDF PubMed Scopus (25) Google Scholar included data demonstrating that GR antisense transgenic mice have a significant increase in thymocyte numbers.
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