Abstract
pact on the skeleton. Bone remodelling is tightly regulated, and bone formation occurs in areas of previously resorbed bone. Bone is continuously regenerated, a process that is undertaken by basic multicellular units. These units are comprised of teams of juxtaposed osteoclasts and osteoblasts. These bone-resorbingand-forming cells maintain bone remodelling in an orderly fashion, and osteoclastogenesis is dependent on the genesis and presence of osteoblasts. The number of bone-forming and bone-resorbing cells present in the basic multicellular units is also dependent on an orderly cellular death or apoptosis. Therefore, cell genesis and death are critical for the maintenance of bone homeostasis. The genesis of osteoblasts and osteoclasts is governed by specific genes, local regulatory factors and various systemic hormones, including glucocorticoids.
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