Abstract

Glucocorticoids have found their chief clinical utility as anti-inflammatory agents. Treatment by these agents brings about a dramatic suppression of all the clinical signs and symptoms of acute and chronic inflammation, that is pain, redness, heat and swelling. Such profound effects of glucocorticoids are generally considered as ‘pharmacological actions’ since they are observed when amounts of steroids experimentally used in in vitro or in vivo studies are present in concentrations greater than those found under natural or physiological conditions.

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