Abstract
Glucocorticoid binding to certain cell particles of rat liver and thymus following treatments in vivo and in vitro consists in part of a very “tight binding” that resists hot and cold perchloric acid extractions. This binding is found in thymus nuclei and in liver cytoplasmic particles, but not in liver nuclei nor in thymus mitochondria or microsomes. The existence of “tight binding” coincides with the ability of the same particles to bind free corticoid directly in incubations in vitro . The difference in the cellular location of this binding suggests that different methods of glucocorticoid activation exist in the anabolic target tissue, liver, and the catabolic target tissue, rat thymus.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: Biochemical and Biophysical Research Communications
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
