Abstract
The influence of adrenalectomy on cannabinoid receptor gene expression in the adult rat dorsal striatum was investigated by in situ hybridization with specific oligonucleotide probes. The caudate-putamen of adrenalectomized rats contains ∼50% significantly higher mRNA levels than the controls. This increase could be counteracted by dexamethasone treatment. Together, these results suggest glucocorticoid down-regulation of cannabinoid receptor gene expression in the striatum.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have