Abstract
In the genetic skin disease psoriasis, the number of Proliferating cells is 12-fold greater in lesional (involved) and 2.5-fold greater in uninvolved epidermis than in normal epidermis. Since increased polyamine biosynthesis is associated with Cell proliferation, we measured polyamine levels and the activities of the polyamine biosynthetic enzymes from biopsies of involved and uninvolved psoriatic epidermis and normal epidermis. Polyamine (putrescine, spermidine, and spermine) levels were: (1) higher in involved than in uninvolved epidermis (N = 7, P
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