Abstract
Synthetic glucocorticoids and progesterone were evaluated for their inhibitory action on estrus in ovariectomized pigs treated with estrogen. Triamcinolone acetonide (~70 μg/kg BW), and dexamethasone (~140 μg/kg BW) inhibited the estrous response to estradiol benzoate when these glucocorticoids were given during a period of 5 days before to 4 days after estradiol benzoate. The minimum effective dosage of progesterone that would inhibit estrus when given concurrently with estradiol benzoate was 600 (μg/kg BW. When triamcinolone acetonide (30 μg/kg BW) or dexamethasone (125 or 150 μg/kg BW) was given as a single injection in combination with progesterone (100 μg/kg BW), estrous response to estradiol benzoate was again inhibited. These steroids at these dosages had no significant effect when either was administered alone. Based on these results, the inhibitory action of these glucocorticoids on estrus in pigs is additive to the action of progesterone, and we suggest that triamcinolone acetonide and dexamethasone inhibit estrus through mechanisms related to those of progesterone.
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