Glucan Coated Iron Oxide Nanoparticles for Regulating Survival, Inflammation and Oxidative Stress in Parkinsons Disease

Abstract

This study assessed the mechanism of Iron Oxide Nanoparticles (IONP) coated with glucan in regulating survival, inflammation and oxidative stress in Parkinson’s disease (PD). IONP coated with glucan (NPs) was established and identified. BV-2 cells were randomly divided into the following three sets; control set, PD set, and NPs set. Apoptotic activity of nerve cells, expression of TNF-α, IL-6 and IL-1β, and content of reactive oxygen species (ROS) and malondialdehyde (MDA) were was also analyzed. The expression of NF-κB and Inductible Nitric Oxide Synthase (iNOS) was detected with Western Blot, while content of glialcellline-derivedneurotrophicfactor (GDNF) was analyzed by Proliferation of nerve cells was prompted and apoptosis was restrained in the NPs set. The levels of TNF-α, IL-6 and IL-1β were reduced while contents of ROS and MDA were reduced. The expression of NF-κB and iNOS were restrained. The levels of inflammatory factors were reduced, while secretion of GDNF was reduced. The survival of nerve cells in the PD was prompted by NPs, while inflammation and oxidative stress were restrained.