Abstract

Polycystic ovary syndrome (PCOS) is one of the common endocrine disorders in reproductive-aged women, which is associated with a serious consequence to infertility. The etiology is not yet clear at present. Hyperandrogenism, insulin resistance (IR) and hyperinsulinemia and other endocrine hormone disorders are the most important characteristics. It has been showed that glucagon-like peptide-1 receptor agonist (GLP-1Ra) can improve IR, lose weight, and have effects on the secretion of testosterone, luteinizing hormone and follicle stimulating hormone, and thus likely to make it possible that GLP-1Ra be used to interfere with the occurrence and development of PCOS. At the same time, GLP-1Ra can also play a role in the development of PCOS associated with type 2 diabetes, cardiovascular disease, and nonalcoholic fatty liver disease. Key words: Polycystic ovary syndrome; Glucagon-like peptide-1 receptor agonist; Insulin resistance; Weight; Sex hormones

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