Abstract
Glucagon-like peptide-1 (GLP-1), a gut-brain hormone, coordinates energy balance in both peripheral organs and the central nervous system (CNS). In the pancreas, GLP-1 facilitates insulin exocytosis or suppresses glucagon exocytosis via multiple pathways such as regulating KATP /Kv channels, N-type Ca2+ channels, and the readily releasable pool. In the CNS, GLP-1 signaling regulates neuronal excitability in various brain regions, including neurons in the hippocampus, hypothalamus, and mesolimbic systems. GLP-1 modulation on synaptic transmission includes both pre- and postsynaptic pathways that are either excitatory or inhibitory. Synaptic transmission conveys information flow in the brain and governs brain-mediated behaviors. The study of GLP-1 control of energy metabolism at a synaptic level may shed light on the role of GLP-1 function in the brain. Various challenges remain including defining the mechanism of GLP-1 release in the brain.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
