Abstract
SUMMARY A fibrin slide technique was utilized to study the relationship between renal homograft rejection and glomerular plasminogen activator activity. Glomerular plasminogen activator activity was absent in tissue from 25 of 30 patients rejecting kidneys within 10 months of transplantation. On the other hand, glomerular activator activity was detected in tissue from patients with acute tubular necrosis after transplantation, in functioning grafts, in grafts rejected more than 2 years after transplantation, and in tissue from 328 patients with a variety of renal diseases. These studies suggest that loss of glomerular plasminogen activator activity may be a diagnostic feature of renal homograft rejection occurring within 10 months of transplantation.
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