Abstract
Advances in the conservative management of patients with chronic renal insufficiency have reaffirmed the need for the accurate measurement of glomerular filtration rate (GFR). The two most readily available indices of GFR are the urea clearance and the creatinine clearance; yet neither accurately reflects GFR in advanced renal disease. Theoretical considerations suggest that when GFR is less than 20ml/min the combined use of urea clearance and creatinine clearance should accurately measure GFR. This thesis was tested in patients with advanced renal insufficiency. In all instances, the mean value for the urea plus creatinine clearance closely approximated the simultaneously determined inulin clearance. Since analyses for both urea and creatinine may be performed on the same samples of blood and urine, the present technique offers an accurate clinical means of measuring GFR in advanced chronic renal disease.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
