Abstract
Diabetes is the main cause of renal failure worldwide. Complications of the kidney micro-and macro-circulation are common in diabetic patients, leading to proteinuria and can progress to end-stage renal disease. Across the complex interplays aggravating diabetes kidney disease progression, lesions of the glomerular filtration barrier appear crucial. Among its components, glomerular endothelial cells are known to be central safeguards of plasma filtration. An array of evidence has recently pinpointed its intricate relations with podocytes, highly specialized pericytes surrounding glomerular capillaries. During diabetic nephropathy, endothelial cells and podocytes are stressed and damaged. Besides, each can communicate with the other, directly affecting the progression of glomerular injury. Here, we review recent studies showing how in vitro and in vivo studies help to understand pathological endothelial cells-podocytes crosstalk in diabetic kidney disease.
Highlights
Diabetes is a multifactorial disease and encompasses multi-organ complications, including kidney lesions leading to diabetic kidney disease (DKD)
In line with these experimental studies, the SONAR trial suggested that the ETA receptor antagonist atrasentan decreases albuminuria and the risk of major kidney outcomes when given to adults with type 2 diabetes, estimated glomerular filtration rate 25–75 mL/min per 1.73 m2, and a urine albumin-to-creatinine ratio (UACR) of 300–5,000 mg/g who had received maximum labeled or tolerated renin–angiotensin system inhibition for at least 4 weeks [10]
Researchers tried to model pathological conditions happening during DKD, by culturing endothelial cells (ECs) and/or podocytes with high glucose (HG)
Summary
Diabetes is the main cause of renal failure worldwide. Complications of the kidney micro-and macro-circulation are common in diabetic patients, leading to proteinuria and can progress to end-stage renal disease. Across the complex interplays aggravating diabetes kidney disease progression, lesions of the glomerular filtration barrier appear crucial. Glomerular endothelial cells are known to be central safeguards of plasma filtration. An array of evidence has recently pinpointed its intricate relations with podocytes, highly specialized pericytes surrounding glomerular capillaries. Endothelial cells and podocytes are stressed and damaged. Each can communicate with the other, directly affecting the progression of glomerular injury. We review recent studies showing how in vitro and in vivo studies help to understand pathological endothelial cells-podocytes crosstalk in diabetic kidney disease
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
