Abstract
Introduction: In early 2015, several patients presenting with dengue-like symptoms were described in Brazil′s northeast region. Reverse transcription polymerase chain reaction (RT-PCR) results from patients′ sera revealed the Zika virus (ZIKV) infection. In parallel,
Highlights
INTRODUCTIONZika virus (ZIKV) is an emerging flavivirus that belongs to the same family as Dengue (DENV), West Nile, and Yellow Fever viruses [1]
In early 2015, several patients presenting with dengue-like symptoms were described in Brazil's northeast region
This report describes a case of Zika virus (ZIKV) intrauterine infection associated with histologic alterations in the newborn kidney tissue
Summary
Zika virus (ZIKV) is an emerging flavivirus that belongs to the same family as Dengue (DENV), West Nile, and Yellow Fever viruses [1]. Histological alterations of the kidney tissue in newborns from ZIKV-infected mothers need a more detailed study to support the affected. The authors aimed to report the histological changes in the kidney tissue detected in a newborn case of intrauterine infection by ZIKV and the involvement of other tissues from a mother with confirmed intrauterine ZIKV infection. The Molecular Virology Laboratory of Carlos Chagas Institute/Fiocruz-PR (ICC/Fiocruz-PR) is one of the official sentinel laboratories assigned by the Brazilian Ministry of Health to perform ZIKV diagnosis In this context, we describe one case of a newborn with congenital ZIKV syndrome. Reverse transcription polymerase chain reaction assays yielded positive results for ZIKV RNA in brain tissue samples and negative for liver and kidney tissue samples [3, 4]. No immunohistochemical evidence of immune complex or complement deposition was demonstrated
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