Abstract
The term “globoid bodies” was first used by Flexner and Noguchi1 in 1913 as a descriptive term for the minute spherical microorganisms cultivated by them from the filterable virus of poliomyelitis. Bashford and Wilson2 likewise cultivated “globoid bodies” from lethargic encephalitis. Duval and I3 have recently described a “globoid microorganism” in cultures of the blood from Dengue fever.The “globoid bodies” described by Flexner and Noguchi consist of minute spheres or “coccoids” measuring from 0.15 to 0.3 microns in diameter and arranged in pairs, short chains, and masses. These bodies are best demonstrated tinctorially by the Giemsa method and are readily seen in dark-field preparations. Cultivation of the “globoids” has been obtained in the Smith-Noguchi tissue media. Growth has also been successful by the employment of Noguchi's Ringer-plasma medium devised for the cultivation of the Leptospira. The culture of the poliomyelitis globoids appears as an opalescent haze about the tissue, increasing for a ...
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