Globally Harmonized System on Hazard Classification and Labeling of Chemicals and Other Existing Classification Systems for Germ Cell Mutagens

Abstract

The Globally Harmonized System (GHS) on hazard clas- sication and labeling of chemicals will be implemented globally by 2008. The GHS includes (a) harmonized criteria for classifying chemicals and chemical mixtures according to their health, environmental and physical hazards, and (b) harmonized hazard communication elements, including requirements for labeling and safety data sheets. Germ cell mutagenicity is included in the GHS health hazard classes in addition to carcinogenicity. This means increased signicance for then results of genetic toxicology testing for the classication of chemicals. GHS requires the classication of chemicals if they are germ cell mutagens (categories 1A, 1B and 2) or not. Several classication systems for germ cell mutagens have been proposed in the EU, Germany, US, Canada, in advance of the adoption of the GHS. In this paper, these classication systems includ- ing GHS are introduced and summarized to provide the basis of the hazard classication of germ cell mutagens. Though the objectives, target audiences and criteria of these classication systems are diSerent, the GHS will become standard for hazard classication. Hazard classiˆ- cation is a signicantrst step in risk communication. Further development of risk evaluation criteria and communication on germ cell mutagens is expected.