Globally Asymptotic Stability Analysis for Genetic Regulatory Networks with Mixed Delays: An M-Matrix-Based Approach

Abstract

This paper deals with the problem of globally asymptotic stability for nonnegative equilibrium points of genetic regulatory networks (GRNs) with mixed delays (i.e., time-varying discrete delays and constant distributed delays). Up to now, all existing stability criteria for equilibrium points of the kind of considered GRNs are in the form of the linear matrix inequalities (LMIs). In this paper, the Brouwer's fixed point theorem is employed to obtain sufficient conditions such that the kind of GRNs under consideration here has at least one nonnegative equilibrium point. Then, by using the nonsingular M-matrix theory and the functional differential equation theory, M-matrix-based sufficient conditions are proposed to guarantee that the kind of GRNs under consideration here has a unique nonnegative equilibrium point which is globally asymptotically stable. The M-matrix-based sufficient conditions derived here are to check whether a constant matrix is a nonsingular M-matrix, which can be easily verified, as there are many equivalent statements on the nonsingular M-matrices. So, in terms of computational complexity, the M-matrix-based stability criteria established in this paper are superior to the LMI-based ones in literature. To illustrate the effectiveness of the approach proposed in this paper, several numerical examples and their simulations are given.