Abstract
This report recapitulates the diverse aspects of biological safety. Biological laboratory is a space that facilitates the handling and storage of microorganisms, their components or their derivatives. Laboratories that handle dangerous pathogens have to act in a responsible manner to manage the safety and security threats posed by these pathogens. This necessity was foreground in the December 2008 World at risk report, which specifically demanded bioscience laboratories that handle dangerous pathogens to implement a unified laboratory biorisk management framework to enhance their safety and security. The report also discusses the guidelines of biosafety regulations provided by World Health Organization (WHO) that are necessary to adequately and sustainably manage these biorisks and helps in better understanding of risk governance approaches for laboratories that handle dangerous pathogens to achieve the ultimate goal of minimizing or preventing the occurrence and consequences of human error within the laboratory environment: the biorisk management approach, composed of biosafety, laboratory biosecurity and ethical responsibility. It preferably provides an agreement between authorities, the public, and the scientific community establishing trust and societal safety and security, while enabling the continued progress of science. Biorisk management approach demonstrates that biorisks in all their potential forms are appropriately addressed, managed and minimized. Thus, biorisk management has become an important aspect of the development and sustainability of biological activities.
Highlights
Management of biological safety and security risks is a difficult and costly venture
If protective equipment (PPE) is not disposable, PPE shall be cleaned with disinfectant before and after use or laundered by an outside vendor by placing it into designated biohazard bags provided by the vendor
Management of Small Spills The following procedures are recommended for a large volume biological spill in the laboratory area, in a Biological safety cabinets (BSCs), or if equipment malfunctions while processing biological materials:
Summary
Management of biological safety and security risks is a difficult and costly venture. Biorisk governance aims at providing a framework for an organization to enable biorisk assessment and biorisk management activities to take place in a sustainable way It improves decision making, planning and prioritisation, and contributes to a more efficient allocation and use of the valuable biological materials (VBM) within a laboratory. Biological risk assessment is a legal obligation in many countries that have biosafety regulations, as part of the notification or authorization process and/or as a basis to determine the required containment levels and other protective or preventive measures. It is a major element of the WHO laboratory biosafety manual and a basis of the laboratory biorisk management standard CWA 157937. These questions have emerged as an important component in the development, regulation and promotion of the products of many new and older technologies such as chemicals and pharmaceuticals
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