Abstract
Atherosclerosis is a pathological vascular state caused by the interaction of environmental and hereditary factors. Epigenetic modifications may be the bridge connecting environmental factors and genetic factors. A search for publications on the Web of Science database in the field of atherosclerosis related to epigenetics was conducted from the earliest mention to 31 December 2020. Data on total and annual publications, citations, impact factors, Hirsch (H)-index, citation times, most prolific authors, and frequently published journals were collected for quantitative and qualitative comparison. A total of 1848 publications related to epigenetics and atherosclerosis were found. The major contributing countries were the China (522, 28.23%), United States (485, 26.23%), and Germany (119, 6.44%). The greatest number of retrieved publications were published in the journal, “Arteriosclerosis, Thrombosis, and Vascular Biology” (62, 3.66%). The publication “Oxidative Stress and Diabetic Complications” was cited 2370 times. The most frequent keywords were “DNA methylation” and “LncRNA”. Publications on epigenetic research in the atherosclerosis field have increased significantly every year, indicating that the study of epigenetic modifications plays an increasingly important role in understanding the pathology of atherosclerosis.
Highlights
The environmentally-induced phenotype is dependent on epigenetic regulation [2], and recent studies have shown that epigenetics plays an important role in the occurrence and development of atherosclerosis [3]
The reversibility of epigenetic modifications may open up new strategies and targets for the treatment of atherosclerosis [7]
Considerable evidence has accumulated demonstrating how epigenetic modification plays an important role in atherosclerosis, more specific research still needs to be explored by scientists
Summary
Publisher’s Note: MDPI stays neutral with regard to jurisdictional claims in published maps and institutional affiliations. Atherosclerosis is a chronic inflammatory disease manifesting with pathological changes in the cardiovascular system caused by the interaction of environmental and genetic factors [1]. The environmentally-induced phenotype is dependent on epigenetic regulation [2], and recent studies have shown that epigenetics plays an important role in the occurrence and development of atherosclerosis [3]. Further explorations into the effects of epigenetic modifications on the formation and development of atherosclerosis are expected to further elucidate the pathogenesis of atherosclerosis [4,5,6]. The reversibility of epigenetic modifications may open up new strategies and targets for the treatment of atherosclerosis [7]
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: International Journal of Environmental Research and Public Health
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
