Abstract
Analysis of genome-wide responses to changing copper and iron levels in budding and fission yeast reveals conservation of only a small core set of genes and remarkable differences in the responses of the two yeasts to excess copper.
Highlights
Recent studies in comparative genomics demonstrate that interspecies comparison represents a powerful tool for identifying both conserved and specialized biologic processes across large evolutionary distances
It is estimated that S. pombe diverged from S. cerevisiae approximately 0.3 to 1.1 billion years ago [5], and many gene sequences are as distantly related between the two yeasts as to their human homologs
We tested a number of concentrations close to the levels that were known to affect growth in S. cerevisiae [19], and selected those that did not negatively affect S. pombe growth rate
Summary
Recent studies in comparative genomics demonstrate that interspecies comparison represents a powerful tool for identifying both conserved and specialized biologic processes across large evolutionary distances. Accurate annotation of sequenced genomes heavily depends on the availability of gene and protein sequences from other species to allow identification and functional characterization of novel genes by similarity [1,2] Another area that benefits from interspecies comparisons through the use of cellular and animal model systems is the study of human disease, in which it is often not possible to investigate underlying defects directly. An excess of free copper can react with oxygen, generating reactive oxygen species that damage cellular components such as nucleic acids, proteins, and lipids To prevent this from happening, specialized homeostatic mechanisms that tightly control the availability of copper within cells are present in virtually all organisms. A comparison between budding and fission yeast can provide valuable information on the degree to which copper pathways have diverged during evolution
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