Abstract
AbstractThe analysis of the spectroscopic and electrochemical properties of all reported classes of Cu/Zn superoxide dismutase mimics (SODm) makes it possible to distinguish the geometric specificity of highly active compounds. A linear relationship with EPR parameters characterises the geometry of the first coordination sphere around the metal, which favours catalytic activity. Combined with the appropriate redox potential values, the model of geometric conformation of highly active Cu/Zn SODm serves to streamline further synthetic efforts. This global analysis represents a new approach to treat all classes of compounds intended for a specific biological activity in order to obtain general features that could orient the process of drug discovery.(© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2009)
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
