Abstract
BackgroundAkkermansia muciniphila is an anaerobic bacterium residing in the healthy intestinal tract of host and its quantity has a negative correlation with various host diseases. This study for the first time provides a holistic bibliometric aspect of Akkermansi muciniphila research in the literature and shows the hot topic terms of these articles in any period of time.MethodsScopus database was selected to retrieve documents relevant to Akkermansia muciniphila in any language up to 2019. The bibliometric profile of Akkermansia muciniphila articles including subject area, year distribution, citations, institutions, journals, authors, and countries was systematically characterized and the collaboration networks of authors and countries as well as the burst detection algorithm of the words in the titles, abstracts and keywords were visualized.ResultsThere is a progressive growing trend in research on Akkermansia from 2004 to 2019 with a total of 566 articles during this period. Out of 353 original articles, there are 194 animal studies (155 studies on mice) and 112 human studies. Also, 65 various diseases were investigated in these studies. The most focused conditions are obesity (71 articles) and type2 diabetes (39 articles). The United States is the leading country on Akkermansia publications (n = 132), followed by China (n = 95). Frontiers in Microbiology is the most dominant journal with 23 Akkermansia publications. In addition, “cancer” is the hot topic of recent Akkermansia research.ConclusionAkkermansia research is of progressive interest during the last decade and the studies on this subject move towards its relationship with cancer and its promising effect on health.
Highlights
Akkermansia muciniphila is an anaerobic bacterium residing in the healthy intestinal tract of host and its quantity has a negative correlation with various host diseases
Many researches show that various diseases e.g. obesity, type II diabetes and inflammatory bowel diseases have an association with reducing A. muciniphila abundance [4,5,6,7,8]
We categorized the type of animals that were utitlized in only animal studies or both animal and other population studies (n = 194) and found that 155 studies were performed in mice, 29 in rat, 2 in poultry and study were performed in each of the following animal population: dog, foals, hamster, marine fish, pig, rabbit and zebrafish
Summary
Akkermansia muciniphila is an anaerobic bacterium residing in the healthy intestinal tract of host and its quantity has a negative correlation with various host diseases. Due to the close presence of this bacterium to the gut epithelium cells, it has a key role in host-microbiota interaction through regulating host metabolic and inflammatory pathways [5, 9]. Animal and human studies show that A. muciniphila consumption could improve several diseases [9, 13, 14]. All these documents reveal the importance of Akkermansia on health conditions. In the current bibliometric study, we are supposed to characterize the recent progress in the research on this domain of literature.
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