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Abstract
We sought datasets with granular age distributions of rotavirus-positive disease presentations among children <5 years of age, before the introduction of rotavirus vaccines. We identified 117 datasets and fit parametric age distributions to each country dataset and mortality stratum. We calculated the median age and the cumulative proportion of rotavirus gastroenteritis events expected to occur at ages between birth and 5.0 years. The median age of rotavirus-positive hospital admissions was 38 weeks (interquartile range [IQR], 25–58 weeks) in countries with very high child mortality and 65 weeks (IQR, 40–107 weeks) in countries with very low or low child mortality. In countries with very high child mortality, 69% of rotavirus-positive admissions in children <5 years of age were in the first year of life, with 3% by 10 weeks, 8% by 15 weeks, and 27% by 26 weeks. This information is critical for assessing the potential benefits of alternative rotavirus vaccination schedules in different countries and for monitoring program impact.
Highlights
To cite this version: Mateusz Hasso-Agopsowicz, Nanji Ladva, Benjamin Lopman, Colin Sanderson, Adam Cohen, et al
In countries with very high child mortality, 69% of rotavirus-positive admissions in children aged
We show that the median age of rotavirus disease varies between and within countries but tends to occur at a much younger age in higher-mortality settings
Summary
To cite this version: Mateusz Hasso-Agopsowicz, Nanji Ladva, Benjamin Lopman, Colin Sanderson, Adam Cohen, et al. Global Review of the Age Distribution of Rotavirus Disease in Children Aged. HAL is a multi-disciplinary open access archive for the deposit and dissemination of scientific research documents, whether they are published or not. The documents may come from teaching and research institutions in France or abroad, or from public or private research centers. L’archive ouverte pluridisciplinaire HAL, est destinée au dépôt et à la diffusion de documents scientifiques de niveau recherche, publiés ou non, émanant des établissements d’enseignement et de recherche français ou étrangers, des laboratoires publics ou privés. Global Review of the Age Distribution of Rotavirus Disease in Children Aged
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