Abstract
BackgroundBoth pulmonary tuberculosis (PTB) and diabetes mellitus (DM) are major global public health problems. We estimated the global, regional, and national prevalence of diabetes mellitus in a population with PTB.MethodsWe searched for observational studies of DM in people with PTB using the PubMed and Embase electronic bibliographic databases, focusing on articles published in the English language from database inception until March 31, 2021. We included original research that reported the prevalence of DM in PTB or those that had sufficient data to compute these estimates. Studies were excluded if they did not provide primary data or were case studies or reviews. Two authors independently extracted the articles and collected detailed information using a predefined questionnaire. A country-specific random-effects meta-analysis was used for countries with two or more available studies, and a fractional response regression model was employed to predict the prevalence of DM in PTB for countries with one or no study. The study was registered with the International Prospective Register of Systematic Reviews, using the registration number CRD42018101989.ResultsWe identified 22,658 studies, and 153, across 51 countries, were retained for data extraction. The global prevalence of DM among patients with PTB was estimated to be 13.73% (95% confidence interval [CI] 12.51–14.95). The prevalence rates were 19.32% (95% CI 13.18–25.46) in the region of the Americas, 17.31% (95% CI 12.48–22.14) in the European region, 14.62% (95% CI 12.05–17.18) in Southeast Asia, 13.59% (95% CI 7.24–19.95) in the western Pacific region, 9.61% (95% CI 4.55–14.68) in the eastern Mediterranean region, and 9.30% (95% CI 2.83–15.76) in the African region. The country with the highest estimated prevalence was the Marshall Islands (50.12%; 95% CI 4.28–95.76).ConclusionComorbid PTB and DM remain prevalent worldwide.
Highlights
Both pulmonary tuberculosis (PTB) and diabetes mellitus (DM) are major global public health problems
16,171 studies were further discarded after their abstracts were read because it appeared that these papers clearly did not meet the criteria, and the full texts of the remaining 519 citations were examined in greater detail; at this point, it appeared that another 366 studies did not meet the inclusion criteria as described
Data were available for 17 studies involving 13 countries in the African region; 15 studies involving six countries in the eastern Mediterranean region; 12 studies involving nine countries in the European region; 33 studies involving seven countries in the region of the Americas; 40 studies involving eight countries in the Southeast Asian region; and 39 studies involving eight countries in the western Pacific region
Summary
Both pulmonary tuberculosis (PTB) and diabetes mellitus (DM) are major global public health problems. Regional, and national prevalence of diabetes mellitus in a population with PTB. Both tuberculosis (TB) and diabetes mellitus (DM) are major global public health problems. Despite laudable progress policies and medical care in the control of TB, the World Health Organization (WHO) reported 10 million cases of TB and 1.3 million TB-related deaths in 2017 [1]. According to another systematic review, DM has a major effect on TB treatment outcomes in that patients with TB and DM are at greater combined risk of treatment failure, relapse, and death than those without [9]. Considering the dual burden of these two diseases, the WHO and the International Union Against Tuberculosis and Lung Disease (“the Union”) launched a collaborative framework, which emphasizes the need to establish a collaborative mechanism between National Tuberculosis Programs and diabetes organizations and to expand the bi-directional screening of TB and DM [10]
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
