Abstract
BackgroundFemale breast cancer (FBC) is a malignancy involving multiple risk factors and has imposed heavy disease burden on women. We aim to analyze the secular trends of mortality rate of FBC according to its major risk factors.MethodsDeath data of FBC at the global, regional, and national levels were retrieved from the online database of Global Burden of Disease study 2017. Deaths of FBC attributable to alcohol use, high body-mass index (BMI), high fasting plasma glucose (FPG), low physical activity, and tobacco were collected. Estimated average percentage change (EAPC) was used to quantify the temporal trends of age-standardized mortality rate (ASMR) of FBC in 1990–2017.ResultsWorldwide, the number of deaths from FBC increased from 344.9 thousand in 1990 to 600.7 thousand in 2017. The ASMR of FBC decreased by 0.59% (95% CI, 0.52, 0.66%) per year during the study period. This decrease was largely driven by the reduction in alcohol use- and tobacco-related FBC, of which the ASMR was decreased by 1.73 and 1.77% per year, respectively. In contrast, the ASMR of FBC attributable to high BMI and high FPG was increased by 1.26% (95% CI, 1.22, 1.30%) and 0.26% (95% CI, 0.23, 0.30%) per year between 1990 and 2017, respectively.ConclusionsThe mortality rate of FBC experienced a reduction over the last three decades, which was partly owing to the effective control for alcohol and tobacco use. However, more potent and tailored prevention strategies for obesity and diabetes are urgently warranted.
Highlights
Female breast cancer (FBC) is the most frequently diagnosed carcinoma in women and is the leading cause of cancer death in over 100 countries [1]
Whereas the age-standardized mortality rate (ASMR) of FBC decreased by 0.59% per year during the study period (Table 1; Fig. 1)
At the Global Burden of Disease (GBD) regional level, the higher ASMR of FBC was mostly observed in regions with advanced economies, including Western Europe, highincome North America, and Australasia, in which the ASMR had experienced a significant decrease (Table 1; Fig. 2)
Summary
Female breast cancer (FBC) is the most frequently diagnosed carcinoma in women and is the leading cause of cancer death in over 100 countries [1]. A favorable trend in FBC mortality rate has been witnessed in recent years, in. The patterns of incidence and mortality of FBC are varied across the world due to the geographical heterogeneities in these risk factors [4]. Understanding the risk pattern of FBC is instrumental to establish more tailored prevention strategies in each country. Female breast cancer (FBC) is a malignancy involving multiple risk factors and has imposed heavy disease burden on women. We aim to analyze the secular trends of mortality rate of FBC according to its major risk factors
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