Global, regional, and national disease burden and attributable risk factors of HIV/AIDS in older adults aged 70years and above: a trend analysis based on the Global Burden of Disease study 2019.

Abstract

We aimed to assess the burden and trend of the HIV/AIDS epidemic among older adults over the past three decades at different geographical levels, based on the data collected from the Global Burden of Diseases (GBD) study 2019. This assessment identified the average annual percentage changes (AAPCs) using Joinpoint regression analysis. Globally, the incidence of HIV/AIDS has decreased (AAPC=-3.107); however, the overall prevalence has consistently increased (AAPC=5.557). Additionally, both mortality (AAPC=2.166) and disability-adjusted life years (DALYs; AAPC=2.429) have increased. The highest increasing trends in female HIV/AIDS incidence and prevalence were observed in the Central Asia region. However, for males, these trends were observed in the Oceania region and the high-income Asia Pacific region, respectively. In recent decades, females aged 70-74years had the highest incidence and prevalence, while males aged 70-74years had highest mortality and DALYs in low social development index (SDI) regions. Unsafe sex resulted in 15381.16 deaths, accounting for 90.73% of all HIV/AIDS deaths, and 331140.56 DALYs, accounting for 91.12% of all HIV/AIDS DALYs. The HIV/AIDS disease burden differs by region, age, and sex among older adults. Sexual health education and targeted screening for older adults are recommended.