Abstract

Endometrial cancer (EC) is the most common malignancy affecting women in developed countries. Recently, the EC disease burden has changed; therefore, the Global Burden of Disease (GBD) 2017 was used to comprehensively analyze the global, regional, and national burden of EC between 1990 and 2017. General GBD cancer estimation methods were used with the data input from vital registration systems and cancer registries. Annual percent changes were calculated to quantify the trends of EC burden estimates during the study period. Furthermore, the sociodemographic index (SDI) was used to assess the relationship between the EC burden estimates and development level. From 1990 to 2017, the age-standardized incidence and prevalence rate of EC increased globally by 0.58 and 0.89% per year, respectively. In contrast, the age-standardized death rate and disability-adjusted-life years (DALYs) decreased by 1.19 and 1.21% per year, respectively. Increasing trends in both the incidence and prevalence were observed in all SDI quintiles, except for the low SDI quintiles, whereas decreasing trends were observed in all SDI quintiles for mortality and DALYs. Additionally, a non-linear association existed for the level of mortality rate, DALYs, and SDI. Of note, there was a strong positive association between a high body mass index and DALYs across all SDI quintiles. In conclusion, EC incidence and prevalence rates are growing globally, whereas the death rate and DALYs decreased between 1990 and 2017. Greater efforts, particularly detailed prevention strategies for reducing obesity, should be performed to reverse this phenomenon.

Highlights

  • Endometrial cancer (EC) is an increasingly problematic gynecological cancer [1]

  • In this study, we report the results of the Global Burden of Disease (GBD) 2017 study on primary EC incidence, prevalence, mortality, disability-adjusted life years (DALYs), years of life lived with disability (YLDs), and years of life lost (YLLs) for 195 countries or territories from 1990 to 2017 and assess the association between these indicators of the disease burden and the sociodemographic index (SDI) level

  • During the entire study period, increasing trends were observed in all SDI quintiles for incidence and prevalence rate of EC, except for the low SDI quintiles

Read more

Summary

Introduction

Endometrial cancer (EC) is an increasingly problematic gynecological cancer [1]. According to the GLOBOCAN cancer statistics, there are an estimated 382,069 new cases and 89,929 deaths attributed to EC worldwide in 2018 [2]. According to the International Agency for Research on Cancer, the incidence rate of EC is increasing rapidly compared with 2018, and is estimated to increase by more than 50% worldwide by 20401. Global Burden of Endometrial Cancer the incidence and mortality of EC differ throughout the world. Mortality rates are increasing in line with incidence [7, 9], decreased mortality is observed in all sociodemographic index (SDI) quintiles, a composite indicator of development status. In this study, we report the results of the Global Burden of Disease (GBD) 2017 study on primary EC incidence, prevalence, mortality, disability-adjusted life years (DALYs), years of life lived with disability (YLDs), and years of life lost (YLLs) for 195 countries or territories from 1990 to 2017 and assess the association between these indicators of the disease burden and the SDI level

Methods
Results
Conclusion
Full Text
Published version (Free)

Talk to us

Join us for a 30 min session where you can share your feedback and ask us any queries you have

Schedule a call