Year-end Sale % OFF 
Abstract
Although gastro-oesophageal reflux disease (GORD) is a common medical complaint, there is currently no consensus on the global prevalence of GORD. The aim of this study was to conduct a systematic review and meta-analysis on GORD prevalence and risk factors at a global level. MEDLINE, EMBASE, CINAHL, Scopus, Cochrane library, and Google Scholar were systematically searched, without language restrictions, for studies on the prevalence and risk factors of GORD. Data were pooled using a random effects model (95% confidence interval), and the odds ratio and relative risk for each risk factor were calculated. Out of 34,355 search results, 96 records reporting the results from 102 studies fulfilled the inclusion criteria, representing 37 countries and all regions of the UN geoscheme. The global pooled prevalence of GORD was 13.98% and varied greatly according to region (12.88% in Latin America and the Caribbean to 19.55% in North America) and country (4.16% in China to 22.40% in Turkey). Using the United Nations 2017 Revision of World Population Prospects, the estimated number of individuals suffering from GORD globally is 1.03 billion. Multiple risk factors associated with a significant increase in the risk of GORD were also identified. This systematic review and meta-analysis revealed that although a substantial proportion (13.98%) of the global population suffers from GORD, there are significant variations between regions and countries. Risk factors for GORD were also identified which may allow clinicians to recognise individuals most at risk.
Highlights
Gastro-oesophageal reflux disease (GORD) is one of the most common complaints in general medical practice and can be a debilitating condition requiring life-long medication, invasive surgery, and lifestyle changes1,2
The aim of the current review was to search the literature systematically using PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) 2009 guidelines and estimate the global prevalence of gastro-oesophageal reflux disease (GORD), the prevalence of GORD according to geographical location and to identify risk factors associated with an increased risk of the condition21
224 records were eligible for full-text review, of which 96 records reporting the results from 102 studies fulfilled the inclusion criteria representing 37 countries and included 469,899 participants (Fig. 1)[27,28,29,30,31,32,33,34,35,36,37,38,39,40,41,42,43,44,45,46,47,48,49,50,51,52,53,54,55,56,57,58,59,60,61,62,63,64,65,66,67,68,69,70,71,72,73,74,75,76,77,78,79,80,81,82,83,84,85,86,87,88,89,90,91,92,93,94,95,96,97,98,99,100,101,102,103,104,105,106,107,108,109,110,111,112,113,114,115,116,117,118,119,120,121,122]
Summary
Gastro-oesophageal reflux disease (GORD) is one of the most common complaints in general medical practice and can be a debilitating condition requiring life-long medication, invasive surgery, and lifestyle changes. It has been estimated that the total direct costs (physician visit, costs of drugs, costs of tests, and hospitalisation) and indirect costs (number of days with total productivity loss and number of days with at least 30% lower functionality) of GORD per patient in Iran during 6 months are $97.90 purchasing power parity dollars (PPP) and $13.70 PPP respectively12 Overall, these statistics highlight the need for this condition to receive more global awareness. A recent systematic review and meta-analysis conducted by Eusebi et al 2017 included 108 studies and assessed the global prevalence of, and risk factors for, gastric reflux symptoms rather the prevalence of GORD18. It is predictable that being aware of the demographics of GORD patients and the risk factors for GORD permits clinicians to identify individuals most at risk, allowing early diagnosis and commencement of treatment, as well as highlighting areas which require more attention from researchers and clinicians
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
