Abstract
Depression in late life is consistently associated with medical comorbidity. This association has been demonstrated in inpatient, ambulatory, and long-term care settings. A broad spectrum of medical disorders, including malignancies, cardiovascular, musculoskeletal, and metabolic disorders, are associated with mood disorders in late life. While vascular mechanisms may predominate in depression following acute vascular events such as stroke or myocardial infarction, the pathways leading to depression in more stable clinical populations remain unclear.
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