Global mapping of protein and lipid network driven by mtor inhibition in oa cartilage

Abstract

Purpose: The mammalian target of rapamycin (mTOR) is a conserved serine-threonine kinase that regulates cellular proliferation, protein synthesis and lipid metabolism in response to metabolic signals. It has been demonstrated that mTOR plays an important role in osteoarthritis (OA) progression and its inhibition protects against joint damage. However, the relevant protein and lipid metabolite network involved on mTOR signaling pathway in OA cartilage ispoorly understood. The objective of this study is to determine the global protein and lipid profiling of human OA cartilage after mTOR inhibition.