Global longitudinal strain and its association with quantitative and qualitative analyses of myocardial perfusion correlate in patients with abnormal SPECT results

Abstract

Abstract Funding Acknowledgements Type of funding sources: None. BACKGROUND Global longitudinal strain (GLS) is being used more commonly in the evaluation of patients with ischemic heart disease (IHD). Even though GLS is known to be associated with infarct size, its relationship with parameters derived from myocardial perfusion studies (MPS) has not been explored enough. AIMS We assessed the correlation of GLS measured with echocardiography with quantitative and qualitive analyses parameters of SPECT-MPS, particularly stress and rest total perfusion deficits (TPDS and TPDR) and summed stress and summed rest scores (SSS and SRS) respectively. METHODS A cross-sectional cohort of patients classified with an abnormal nuclear medicine result using SPECT were tested with doppler echocardiography in a center of reference in Mexico City. Pearson correlation tests and polynomial regression models were used to extract the correlation coefficient and the explained variability for each variable. RESULTS 122 subjects with abnormal nuclear medicine results were assessed. 87 (71.3%) were male with a mean left ventricular GLS of -16 (±5), SRS of 12.9 (±14.5), SSS of 18 (±15.8), TPDR of 12 (±14.3) and TPDS of 17.7 (±15.6). We observed a negative cubic adjusted correlation between GLS and TPDR (r = 0.501, 95% CI: 0.336-0.637, p= <0.001), TPDS (r = 0.470, 95% CI: 0.300-0.612, p= <0.001), SRS (r = 0.472, 95% CI: 0.302-0.613, p= <0.001) and SSS (r = 0.460, 95% CI: 0.288-0.603, p= <0.001). CONCLUSION GLS has a moderate cubic correlation with a negative leading coefficient with TPDR, TPDS, SRS and SSS. This data suggests that GLS may be an adequate parameter for assessing patients with IHD. Abstract Figure. Scatter plot with regression model