Abstract
ObjectiveIntracoronary cardiosphere‐derived cells (icCDCs) exert beneficial effects on left ventricular (LV) function in experimental models of myocardial infarction (MI), but the role of microvascular remodeling and improvements in myocardial perfusion are unclear. We determined whether global icCDCs administered after reperfusion promote functional repair by improving myocardial blood flow in a swine model of acute MI.MethodsImmunosuppressed swine (cyclosporine 100 mg/day, n=15) underwent a 60‐minute LAD occlusion. After 30 minutes of reperfusion, animals were randomized to receive vehicle or 20 x 106 allogeneic CDCs infused into the 3 major coronary arteries at 106 cells/min under continuous flow. LV function (CT) and myocardial perfusion (microspheres) were assessed at baseline and 1‐month after MI, at which point the heart was excised for histological assessment of microvascular density.ResultsSegmental wall thickening in the infarct, border, and remote myocardium was higher in icCDC‐ vs. vehicle‐treated animals (Table). As a result, there was a significant improvement in LV ejection fraction (57.7 ± 2.7 vs. 50.7 ± 4.1%, p<0.05). However, resting and adenosine‐dilated blood flow remained similar between groups, with a comparable density of arterioles and capillaries throughout the LV in each group. imageConclusionThe functional improvement afforded by allogeneic icCDCs administered immediately after acute MI is independent of angiogenesis with no changes in microvascular density or myocardial perfusion.SupportNational Heart Lung and Blood Institute (HL‐055324, 1F32HL‐114335)
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