Abstract
BackgroundAbnormalities of functional connectivity (FC) in certain brain regions are closely related to the pathophysiology of major depressive disorder (MDD). Findings are inconsistent with different presuppositions in regions of interest. Our research focused on voxel-wise brain-wide FC changes in patients with MDD in an unbiased manner.MethodWe examined resting-state functional MRI in 23 patients with MDD and 26 healthy controls. Imaging data were analyzed by using global-brain FC (GFC) and used to explore the correlation of abnormal GFC values with clinical variables.ResultsIncreased GFC values in the left medial superior frontal gyrus (SFGmed) and decreased GFC values in the right supplementary motor area (SMA) were observed in the patients with MDD compared with the controls. The decreased GFC values in the right SMA had a positive correlation with vitamin D and Hamilton Anxiety Scale (HAM-A) scores.ConclusionAbnormal GFC in the hate circuit, particularly increased GFC in the left SFGmed and decreased GFC in the right SMA, appears to be a new sight for comprehending the pathological alterations in MDD.
Highlights
Typical signs of major depressive disorder (MDD) include persistent negative emotions, reduced volitional activity, and cognitive dysfunction
This study aims to utilize the global-brain functional connectivity (GFC) method, which belongs to the analysis method of the functional connectome, to probe the functional connectivity (FC) alterations in the whole brain of patients with MDD based on the aforementioned studies in MDD
Five patients and four controls were excluded because they had excessive head movement during functional MRI scans after preprocessing the neuroimaging data
Summary
Typical signs of major depressive disorder (MDD) include persistent negative emotions, reduced volitional activity, and cognitive dysfunction. MDD brings a heavy burden to the patients and their families due to its significant characteristics of high morbidity and mortality. Several abnormal biochemical serum indices exhibit potential diagnostic significance for MDD. The levels of some monoamine metabolites are significantly associated with the incidence of MDD (Richelson, 2001; Moret and Briley, 2011). Abnormalities of functional connectivity (FC) in certain brain regions are closely related to the pathophysiology of major depressive disorder (MDD). Findings are inconsistent with different presuppositions in regions of interest. Our research focused on voxel-wise brain-wide FC changes in patients with MDD in an unbiased manner
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