Global epidemiology and prevention of colorectal cancer

Abstract

Characterisation of the global variation in disease burden and temporal trends can provide important clues about disease aetiology and inform prevention strategies. Although previous studies have reported geographical and temporal trends in the incidence of and mortality due to colorectal cancer based on data from the GLOBOCAN database, 1 Sung H Ferlay J Siegel RL et al. Global Cancer Statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2021; 71: 209-249 Crossref PubMed Scopus (13427) Google Scholar , 2 Arnold M Sierra MS Laversanne M Soerjomataram I Jemal A Bray F Global patterns and trends in colorectal cancer incidence and mortality. Gut. 2017; 66: 683-691 Crossref PubMed Scopus (2385) Google Scholar , 3 Lu B Li N Luo CY et al. Colorectal cancer incidence and mortality: the current status, temporal trends and their attributable risk factors in 60 countries in 2000–2019. Chin Med J. 2021; 134: 1941-1951 Crossref PubMed Scopus (7) Google Scholar , 4 Arnold M Abnet CC Neale RE et al. Global burden of 5 major types of gastrointestinal cancer. Gastroenterology. 2020; 159: 335-349 Summary Full Text Full Text PDF PubMed Scopus (305) Google Scholar data on disability-adjusted life years (DALYs) due to colorectal cancer and the contributing risk factors remain sparse. Global, regional, and national burden of colorectal cancer and its risk factors, 1990–2019: a systematic analysis for the Global Burden of Disease Study 2019The increase in incidence rates in people younger than 50 years requires vigilance from researchers, clinicians, and policy makers and a possible reconsideration of screening guidelines. The fast-rising burden in low SDI and middle SDI countries in Asia and Africa calls for colorectal cancer prevention approaches, greater awareness, and cost-effective screening and therapeutic options in these regions. Full-Text PDF Open Access