Global classical and weak solutions of the prion proliferation model in the presence of chaperone in a banach space

Abstract

<p style='text-indent:20px;'>The present work is based on the coupling of prion proliferation system together with chaperone which consists of two ODEs and a partial integro-differential equation. The existence and uniqueness of a positive global classical solution of the system is proved for the bounded degradation rates by the idea of evolution system theory in the state space <inline-formula><tex-math id="M1">\begin{document}$ \mathbb{R} \times \mathbb{R} \times L_{1}(Z,zdz). $\end{document}</tex-math></inline-formula> Moreover, the global weak solutions for unbounded degradation rates are discussed by weak compactness technique.</p>