Global burden of oesophageal and gastric cancer by histology and subsite in 2018

Melina Arnold,Isabelle Soerjomataram,Jacques Ferlay,Mark I Van Berge Henegouwen

doi:10.1136/gutjnl-2020-321600

Abstract

ObjectivesTo provide updated estimates of the global burden of oesophageal and gastric cancer by subsite and type.MethodsUsing data from population-based cancer registries, proportions of oesophageal adenocarcinoma (OAC) and squamous cell...

Highlights

With more than 1.5 million new cases estimated in 2018, gastric cancer (GC) and oesophageal cancer belong to the most commonly diagnosed malignancies worldwide.[1 2]
About 70% of all oesophageal cancers occurred in men, who had proportionally more oesophageal adenocarcinoma (OAC) than women (16% vs 11%)
In this study presenting most up-to-d ate estimates of the global incidence of oesophageal cancer and GC by subtype and subsite, we provide a comprehensive picture of the current epidemiological profile of these two cancers

Summary

Introduction

With more than 1.5 million new cases estimated in 2018, gastric cancer (GC) and oesophageal cancer belong to the most commonly diagnosed malignancies worldwide.[1 2] Both are associated with a high disease-related mortality, resulting in close to 1.3 million deaths in the same year.[1,2,3] Given their anatomic proximity, both sites share a number of risk factors and epidemiological features, and display distinct geographical and temporal patterns in incidence. Differences in the distribution of tumour subtypes across populations have been found to partly explain these differentials in the burden from GC and oesophageal cancer.[4 5]. How might it impact on clinical practice in the foreseeable future? How might it impact on clinical practice in the foreseeable future? ►► This quantification of the global burden of subtype-s pecific/subsite-specific incidence provides an important evidence base for clinicians and health policy-makers to plan appropriate cancer control and to impact cancer burden in the future. ►► As incidence patterns shift, driven by ongoing changes in the prevalence of underlying risk factors, changing patient profiles will require an adaptation of current management and resource allocation.

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