Abstract
Occult hepatitis B virus (HBV) infection is characterised by the persistence of replication-competent HBV DNA in the liver (with or without HBV DNA in the blood) of individuals testing negative for HBsAg, using currently available assays.1 Occult HBV infection represents a phase of the natural history of HBV infection,2 in which HBV DNA in the form of a covalently closed circular DNA minichromosome has suppressed replicative activity and gene expression with extremely low rates of virion production.
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