Glme: An R package for mixed effects model inference by the generalized approach

Abstract

This article documents the use of the glme package, which performs generalized inferences based on exact distributions and exact probability statements, provided by such papers as Weerahandi and Yu (2020) under the widely used Compound Symmetric Covariance structure. The underlying model and comparative results of the simulation study for the model with the counterparts are the maximum likelihood method and restricted maximum likelihood method, and illustrative examples; desired future research is also provided.