Gliosarcoma as a rare variant of glioblastoma: 6-Case clinical trial and literature review

Abstract

Gliosarcoma is a rare and highly malignant central nervous system tumor that accounts for 1% to 8% of glioblastomas; it usually occurs in middle-aged and older adults between 40 and 60 years of age and is rare in children. Here in, we present a retrospective study of 6 cases of gliosarcomas diagnosed at the Mohamed V Military Instruction Hospital (HMIMV). A review of clinical, radiological, therapeutic and evolutionary data was carried out. Treatment consisted of a complete macroscopic resection for 5 patients, completed with an adjuvant radiotherapy with temozolomide, the median survival time of our cases was 9,4 months. As a conclusion, there is a lack of a definitive treatment that significantly improves prognosis for gliosacroma’s tumor, so more case reports of GS should be conducted, which would allow a clearer diagnosis and improved treatment methods and prognoses.